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Even if many branded and generic antidepressants are approved for the management of major depressive disorder MDD in Canada, efficacy and tolerability differ among patients, and new-fangled treatment options are needed. Three antidepressants, vortioxetine, levomilnacipran extended-release ER , and vilazodone have lately become available in Canada. The aim of this review is to contextualize differences in their mechanistic and clinical profiles, by this means providing practitioners with knowledge towards support treatment decisions.
In trials versus placebo, each drug improved depressive symptoms in adult patients with MDD. Vortioxetine may as well improve cognitive functioning in MDD, and has proven efficacious all the rage relapse prevention.
Nausea was the most commonly reported adverse happening AE ; rates of libidinous dysfunction were low and rude discontinuation was well tolerated. Levomilnacipran ER, a serotonin norepinephrine reuptake inhibitor, demonstrated greater improvement against placebo in functional impairment to the same degree well as depressive symptoms; dressed in post hoc analyses, improvement inside symptoms of motivation and puissance were observed. Nausea was the most commonly reported AE; regular discontinuation is recommended to dodge discontinuation syndrome.
Vilazodone is a serotonin reuptake inhibitor and not total serotonergic 5-HT 1A receptor agonist. In addition to improvement stylish depressive symptoms, evidence suggests so as to vilazodone may be particularly extravagantly suited for depressed patients along with high anxiety levels. Diarrhea, unsettled stomach, and headache were the big end common AEs; low rates of sexual dysfunction were reported.
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